HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1994788Generated: October 31, 2026
Lawesson's reagent → 7-[[(2-methoxyphenyl)sulfonyl](methyl)amino]-1H-indole-2-carbothioamide
https://huagongshe.com/reaction/1994788
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | 7-[[(2-methoxyphenyl)sulfonyl](methyl)amino]-1H-indole-2-carboxamide | HCID 57476177 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 7-[[(2-methoxyphenyl)sulfonyl](methyl)amino]-1H-indole-2-carbothioamide | HCID 59135976 | 154.9% |
Reaction Steps
A mixture of 7-[[(2-methoxyphenyl)sulfonyl](methyl)amino]-1H-indole-2-carboxamide (2.82 g), Lawesson's reagent (1.6 g) and tetrahydrofuran (250 mL) was stirred at 70° C. for 3 hr. The reaction solution was concentrated under reduced pressure, and the obtained oil was crystallized from ethyl acetate-hexane to give the title compound (2.3 g, yield: 78%) as pale-yellow crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07652133B2 |
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| Source dataset | uspto-grants-2010_01 |
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| ORD ID | ord-8b487077284e4b8c9c10d42a346ea3e9 |
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| Source note | uspto-grants-2010_01 |
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