反应详情

198 g of compound obtained according to (b) is dissolved in 500 ml of 2 N NaOH, and 500 ml of methanol and 150 g of methyl iodide are added. The reaction mixture is stirred at 20° to 30° C. for 6 hours. The crystals which have formed are filtered off with suction, washed and dried to yield 174.5 g of final product (dried in vacuo at 40° C.); white crystals; melting point 115° to 116° C.; yield 82.3% of theory.

1. customThe crystals which have formed
2. filtrationare filtered off with suction
3. washwashed
4. customdried