Methanol → 4-Amino-6-(1-methylcyclopropyl)-3-methylthio-1,2,4-triazin-5-one

HRID 1995028Notes

Reaction equation

HRID 1995028 reaction equation
[NH2:1][N:2]1[C:7](=[O:8])[C:6]([C:9]2([CH3:12])[CH2:11][CH2:10]2)=[N:5][N:4]=[C:3]1[SH:13].[CH3:14]O.CI>[OH-].[Na+]>[NH2:1][N:2]1[C:7](=[O:8])[C:6]([C:9]2([CH3:12])[CH2:10][CH2:11]2)=[N:5][N:4]=[C:3]1[S:13][CH3:14]

Participants

5

Reactant 3

HCID 887MethanolHCID 6328Methyl iodideHCID 178421680HCID 178421680, compound

Product 1

HCID 204889204-Amino-6-(1-methylcyclopropyl)-3-methylthio-1,2,4-triazin-5-oneYield 82.3%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

198 g of compound obtained according to (b) is dissolved in 500 ml of 2 N NaOH, and 500 ml of methanol and 150 g of methyl iodide are added. The reaction mixture is stirred at 20° to 30° C. for 6 hours. The crystals which have formed are filtered off with suction, washed and dried to yield 174.5 g of final product (dried in vacuo at 40° C.); white crystals; melting point 115° to 116° C.; yield 82.3% of theory.

Workup

  1. customThe crystals which have formed
  2. filtrationare filtered off with suction
  3. washwashed
  4. customdried

Sources & evidence

ORD record
ord-43aaa1ef63c745ed8c05b41eef92b18e
Source dataset
uspto-grants-1983_09
Patent number
US04402733

Reaction notes

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