HCID 88662971, compound → HCID 70436618, compound

HRID 1995047Notes

Reaction equation

HRID 1995047 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([NH:9][CH:10]1[C:25](=[O:26])[N:12]2[C:13]([C:22]([OH:24])=[O:23])=[C:14](OS(C)(=O)=O)[CH2:15][S:16][C@H:11]12)=[O:8]>C(O)C>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]([NH:9][CH:10]1[C:25](=[O:26])[N:12]2[C:13]([C:22]([OH:24])=[O:23])=[CH:14][CH2:15][S:16][C@H:11]12)=[O:8]

Participants

3

Reactant 1

HCID 88662971HCID 88662971, compound

Product 1

HCID 70436618HCID 70436618, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 200 mg. portion of 7-(thien-2-ylacetamido)-3-methanesulfonyloxyl-3-cephem-4-carboxylic acid was dissolved in a working fluid containing 2.5 mg./ml. of the starting compound, 35% by volume of ethanol, and 64% by volume of 1.0 molar pH 7.0 McIlvaine buffer. The measured pH of the working fluid was 7.5. The electrolysis was carried out as described in Example 1 in the same type of cell described in Example 1, and the product was worked up as described in Example 2 to obtain about 130 mg. of crude product. The product was converted to the methyl ester, and submitted to mass spectroscopy, which revealed the presence of molecular ions of mass 337 and 338, confirming that the desired product was obtained.

Workup

  1. additioncontaining 2.5 mg
  2. customto obtain about 130 mg

Sources & evidence

ORD record
ord-2752ce02705b4e3eb6d41414307422b3
Source dataset
uspto-grants-1983_09
Patent number
US04402803

Reaction notes

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