HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 2-Chloro-5-phenylpyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 5-phenyl-1H-pyrazin-2-one | HCID 599037 | — |
| Product | 2-Chloro-5-phenylpyrazine | HCID 1236664 | — |
Reaction Steps
A mixture of 0.01 mol. of 5-phenylpyrazin-2(1H)one 8.0 ml. of POCl3 and a drop of concentrated sulfuric acid is refluxed for 4-5 hr. The solution is poured into 100 g. of ice. The title compound is isolated by filtration and recrystallized.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04402958 |
| Source dataset | uspto-grants-1983_09 |
| ORD ID | ord-2130e3284caf45838b838060e626ad40 |
| Source note | uspto-grants-1983_09 |