Methanol, 1,1-diethoxy-, 1-acetate → 8-Phenyl[1,2,4]triazolo[4,3-a]pyrazine

HRID 1995063Notes

Reaction equation

HRID 1995063 reaction equation
C(OC(O[CH2:10][CH3:11])OCC)(=O)C.[NH:12]([C:14]1[C:19]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[N:18]C=[CH:16][N:15]=1)[NH2:13]>>[C:20]1([C:19]2[C:14]3[N:15]([CH:16]=[N:13][N:12]=3)[CH:10]=[CH:11][N:18]=2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 84166Methanol, 1,1-diethoxy-, 1-acetateHCID 13199871HCID 13199871, compound

Product 1

HCID 131998808-Phenyl[1,2,4]triazolo[4,3-a]pyrazine

Procedure

To 10 ml. of stirred diethoxymethyl acetate at room temperature is added, in portions, 2.0 g. of 2-hydrazino-3-phenylpyrazine. The reaction mixture is stirred at room temperature and after one hour the precipitated product is collected, washed with ethanol and air dried. The crude product is recrystallized from acetonitrile to yield 1.1 g. of the product of the example as tan needles, m.p. 238°-239° C.

Workup

  1. customis collected
  2. washwashed with ethanol and air
  3. customdried
  4. customThe crude product is recrystallized from acetonitrile
  5. customto yield 1.1 g

Sources & evidence

ORD record
ord-afd61dbdc10c45aea8422b593915c48e
Source dataset
uspto-grants-1983_09
Patent number
US04402958

Reaction notes

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