Triethyl orthoacetate → 3-Methyl-8-phenyl[1,2,4]triazolo[4,3-a]pyrazine

Participants

Reaction Steps

A solution of 0.78 g. of 2-hydrazino-3-phenylpyrazine in 6.0 ml. of triethyl orthoacetate is heated under reflux for one hour. The reaction mixture is cooled in an ice bath and the precipitated solid is collected by filtration. The solid is recrystallized from ethanol to give 0.49 g. of the desired product as tan crystals, m.p. 178°-180° C.

Provenance & Evidence