反应详情

A mixture of 5.5 parts of 1-(4-methoxyphenyl)-4-[2-(methylthio)-1H-imidazol-1-yl]piperazine, 8 parts of Raney-nickel catalyst and 80 parts of methanol is stirred and refluxed overnight. The Raney-nickel is filtered off and another 8 parts of Raney-nickel catalyst are added. The whole is further stirred and refluxed overnight. The reaction mixture is filtered and the filtrate is evaporated. The residue is crystallized from 1,1'-oxybisbutane. The product is filtered off and dried, yielding 3.6 parts (77%) of 1-(1H-imidazol-1-yl)-4-(4-methoxyphenyl)piperazine, mp. 158.6° C.

1. temperaturerefluxed overnight
2. filtrationThe Raney-nickel is filtered off
3. additionanother 8 parts of Raney-nickel catalyst are added
4. stirringThe whole is further stirred
5. temperaturerefluxed overnight
6. filtrationThe reaction mixture is filtered
7. customthe filtrate is evaporated
8. customThe residue is crystallized from 1,1'-oxybisbutane
9. filtrationThe product is filtered off
10. customdried