Formamidine acetate → HCID 20455087, compound

HRID 1995082Notes

Reaction equation

HRID 1995082 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([NH:15][C:16]([NH:18][NH2:19])=[O:17])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[C:20](O)(=O)C.C(=N)N>O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([N:15]3[CH:20]=[N:19][NH:18][C:16]3=[O:17])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 160693Formamidine acetateHCID 20455093HCID 20455093, compound

Product 1

HCID 20455087HCID 20455087, compoundYield 68%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

6.5 Parts of N-[4-(4-methoxyphenyl)-1-piperazinyl]hydrazinecarboxamide and 6.5 parts of methanimidamide acetate (1:1) are melted together for 1 hour at 140° C. Water is added to the melt. The solid product is filtered off and crystallized from 1-butanol, yielding 4.5 parts (68%) of 2,4-dihydro-4-[4-(4-methoxyphenyl)-1-piperazinyl]-3H-1,2,4-triazol-3-one.

Workup

  1. filtrationThe solid product is filtered off
  2. customcrystallized from 1-butanol

Sources & evidence

ORD record
ord-87026481cfa04a7e99fc46508198b156
Source dataset
uspto-grants-1983_09
Patent number
US04402957

Reaction notes

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