Hydrochloric Acid → HCID 12799876, compound

Participants

Reaction Steps

On operating as in Example 1, but starting from 4.4 g of ethyl quinoline-4-carboxylate, 5.6 g of ethyl 3-[3-(N-benzoyl)piperidyl]propionate and 12 ml of a 20% suspension of potassium hydride in oil, 2.7 g of crude product are isolated, which are absorbed on a column containing 270 g of silica. After elution with a 9/1 chloroform-diethylamine mixture, 1.2 g of 1-(4-quinolyl)-3-(3-piperidyl)-1-propanone are obtained, which is converted into its monohydrochloride. This monohydrochloride melts at 163° C.

Provenance & Evidence