Potassium Iodide → HCID 20402707, compound

HRID 1995098Notes

Reaction equation

HRID 1995098 reaction equation
[C:1]([C:9]1[C:10]([NH:16][C:17](=[O:20])[CH2:18]Cl)=[CH:11][N:12]([CH3:15])[C:13]=1[CH3:14])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[I-:21].[K+]>C(O)C>[C:1]([C:9]1[C:10]([NH:16][C:17](=[O:20])[CH2:18][I:21])=[CH:11][N:12]([CH3:15])[C:13]=1[CH3:14])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 4875Potassium IodideHCID 20402708HCID 20402708, compound

Product 1

HCID 20402707HCID 20402707, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-(4-benzoyl-1,5-dimethyl(1H)pyrrol-3-yl)2-chloroacetamide (0.741 mole) and potassium iodide (1.62 mole) were refluxed in ethanol (3400 ml) for 5 hours with stirring. The reaction mixture was then cooled, the inorganic salts were filtered off and the solvent was evaporated under vacuum. The obtained residue was purified by washing first with water and then with cold ethanol. M.p. 135°-137° C. Yield 87%.

Workup

  1. temperatureThe reaction mixture was then cooled
  2. filtrationthe inorganic salts were filtered off
  3. customthe solvent was evaporated under vacuum
  4. customThe obtained residue was purified
  5. washby washing first with water

Sources & evidence

ORD record
ord-5b0c6240e9054f30a69c9a3fee9ae5b8
Source dataset
uspto-grants-1983_09
Patent number
US04402970

Reaction notes

Loading…