HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1995158Generated: October 29, 2026
p-Toluenesulfonic acid → (1R,cis) 2,2-dimethyl-3-[Z-2-(isopropoxycarbonyl)-ethenyl]-cyclopropane-carboxylic acid
https://huagongshe.com/reaction/1995158
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | tert.-butyl(1R,cis)2,2-dimethyl-3-[Z-2-(isopropoxycarbonyl)-ethenyl]-cyclopropane-carboxylate | HCID 86739004 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (1R,cis) 2,2-dimethyl-3-[Z-2-(isopropoxycarbonyl)-ethenyl]-cyclopropane-carboxylic acid | HCID 12807755 | 80.2% |
Reaction Steps
A mixture of 1.4 g of the product of Step B, 100 mg of p-toluene sulfonic acid and 14 ml of toluene was stirred at 120° C. for 21/2 hours and was then evaporated to dryness under reduced pressure. The residue was crystallized from isopropyl ether, was cooled and filtered. The product was dried to obtain 900 mg of (1R,cis) 2,2-dimethyl-3-[Z-2-(isopropoxycarbonyl)-ethenyl]-cyclopropane-carboxylic acid melting at 98° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04402972 |
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| Source dataset | uspto-grants-1983_09 |
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| ORD ID | ord-808f4543eb984392a27702946e3d67f3 |
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| Source note | uspto-grants-1983_09 |
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