HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1995180Generated: October 30, 2026
p-Toluenesulfonic acid → (1R,cis) 2,2-dimethyl-3-[Z-2-(propargyloxycarbonyl)-ethenyl]-cyclopropane-carboxylic acid
https://huagongshe.com/reaction/1995180
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | tert.-butyl(1R,cis)2,2-dimethyl-3-[Z-2-(propargyloxy-carbonyl)-ethenyl]cyclopropane-carboxylate | HCID 86739014 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (1R,cis) 2,2-dimethyl-3-[Z-2-(propargyloxycarbonyl)-ethenyl]-cyclopropane-carboxylic acid | HCID 86739015 | 99.6% |
Reaction Steps
A mixture of 2.0 g of the product of Step A, 0.2 g of p-toluene sulfonic acid and 20 ml of anhydrous toluene was refluxed for 10 minutes and was cooled to 0° C. and stirred for 30 minutes. The mixture was filtered and the filtrate was evaporated to dryness under reduced pressure to obtain 1.59 g of (1R,cis) 2,2-dimethyl-3-[Z-2-(propargyloxycarbonyl)-ethenyl]-cyclopropane-carboxylic acid which was used as is for the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04402972 |
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| Source dataset | uspto-grants-1983_09 |
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| ORD ID | ord-cb102b78465e4a5d955f898e5237f867 |
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| Source note | uspto-grants-1983_09 |
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