3-(2-Chloroethyl)-3-azabicyclo[3.2.2]nonane--hydrogen chloride (1/1) → HCID 13189012, compound

HRID 1995288Notes

Reaction equation

HRID 1995288 reaction equation
[CH3:1][C:2]([C:5]1[CH:10]=[CH:9][C:8]2[C:11]3[CH2:16][CH2:15][NH:14][CH2:13][C:12]=3[C:17](=[O:19])[O:18][C:7]=2[CH:6]=1)([CH3:4])[CH3:3].[ClH:20].[Cl:21][CH2:22][CH2:23][N:24]1[CH2:30][CH:29]2[CH2:31][CH2:32][CH:26]([CH2:27][CH2:28]2)[CH2:25]1>>[ClH:21].[ClH:20].[CH:29]12[CH2:31][CH2:32][CH:26]([CH2:27][CH2:28]1)[CH2:25][N:24]([CH2:23][CH2:22][N:14]1[CH2:15][CH2:16][C:11]3[C:8]4[CH:9]=[CH:10][C:5]([C:2]([CH3:1])([CH3:3])[CH3:4])=[CH:6][C:7]=4[O:18][C:17](=[O:19])[C:12]=3[CH2:13]1)[CH2:30]2

Participants

3

Reactant 2

HCID 126123263-(2-Chloroethyl)-3-azabicyclo[3.2.2]nonane--hydrogen chloride (1/1)HCID 131369218-(1,1-Dimethylethyl)-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]pyridin-5-one

Product 1

HCID 13189012HCID 13189012, compoundYield 48%

Procedure

Prepared by the method described for Example 1 from 8-(1,1-dimethylethyl)-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-c]-pyridin-5-one (4 g, 0.016 moles) and 3-(2-chloroethyl)-3-azabicyclo(3.2.2)nonane hydrochloride (3.6 g, 0.016 moles). Recrystallization from methanol gave the product (3.7 g), mp 312°-315° C.

Workup

  1. customPrepared by the method
  2. customRecrystallization from methanol

Sources & evidence

ORD record
ord-c72ba606ad7f4463a21170f80ff223ff
Source dataset
uspto-grants-1983_09
Patent number
US04404138

Reaction notes

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