HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-[2-(3-Azabicyclo[3.2.2]non-3-yl)ethyl]-1,2,3,4-tetrahydro-7,8-dimethoxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-(2-Chloroethyl)-3-azabicyclo[3.2.2]nonane--hydrogen chloride (1/1) | HCID 12612326 | — |
| Reactant | HCID 13136912 | HCID 13136912 | — |
| Product | 3-[2-(3-Azabicyclo[3.2.2]non-3-yl)ethyl]-1,2,3,4-tetrahydro-7,8-dimethoxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one dihydrochloride | HCID 20488149 | 8.8% |
Reaction Steps
Prepared by the method described in Example 9 from 1,2,3,4-tetrahydro-7,8-dimethoxy-5H-[1]benzopyrano[3,4-c]pyridin-5-one hydrochloride (6.0 g, 0.020 moles), triethylamine (4.0 g, 0.040 moles), and 3-(2-chloroethyl)-3-azabicyclo[3.2.2]nonane hydrochloride (5.4 g, 0.024 moles). Recrystallization from 95% ethanol and then from methanol yielded the product (0.85 g) as the dihydrochloride, mp 255°-258° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04404138 |
| Source dataset | uspto-grants-1983_09 |
| ORD ID | ord-26520752b71e464590e970e00319beec |
| Source note | uspto-grants-1983_09 |