3,4,5,6-tetrahydro-2H-azepin-7-amine → HCID 13066358, compound

Participants

Reaction Steps

To a solution of 11.2 g. of 7-amino-3,4,5,6-tetrahydro-2H-azepine in 100 ml. ethanol 13.1 g. of ethyl 2-formyl-propionate are added at room temperature and the reaction mixture is stirred for 24 hours and boiled for 3 hours. Ethanol is then evaporated at reduced pressure and the residue is treated with a mixture of acetone and petroleum ether. The precipitated crystals are filtered. 6.6 g. (37%) of 3-methyl-2-oxo-2,6,7,8,9,10-hexahydro-pyrimido[1,2-a]azepine are obtained, melting at 202° C. after boiling in acetone.

Provenance & Evidence