Acetone → HCID 20488288, compound

HRID 1995315Notes

Reaction equation

HRID 1995315 reaction equation
[O:1]=[C:2]1[N:7]2[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:6]2=[N:5][CH:4]=[C:3]1[C:13]([O:15][CH2:16][CH3:17])=[O:14].[CH3:18]C(C)=O.C[I:23]>C(OCC)C>[I-:23].[CH2:16]([O:15][C:13]([C:3]1[C:2](=[O:1])[N:7]2[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:6]2=[N+:5]([CH3:18])[CH:4]=1)=[O:14])[CH3:17]

Participants

5

Reactant 3

HCID 180AcetoneHCID 6328Methyl iodideHCID 12778916HCID 12778916, compound

Product 1

HCID 20488288HCID 20488288, compoundYield 43%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1.18 g. of ethyl 4-oxo-4,6,7,8,9,10-hexahydro-pyrimido[1,2-a]azepine-3-carboxylate is dissolved in 12 ml. of acetone and allowed to stand for 24 hours at room temperature in the presence of 1.25 ml. of methyl iodide. The reaction mixture is diluted with diethyl ether. The precipitated crystals are filtered. 0.8 g. (43%) of 3-ethoxycarbonyl-1-methyl-4-oxo-4,6,7,8,9,10-hexahydro-pyrimido[1,2-a]azepinium iodide is obtained melting at 202°-204° C.

Workup

  1. filtrationThe precipitated crystals are filtered

Sources & evidence

ORD record
ord-1f1b52d478ca4c91ae6b5994a50b6a8e
Source dataset
uspto-grants-1983_09
Patent number
US04404205

Reaction notes

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