Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate → HCID 86739019, compound

HRID 1995330Notes

Reaction equation

HRID 1995330 reaction equation
[C:1]([CH2:5][CH:6]([CH3:10])[C:7](Cl)=[O:8])([O:3]C)=[O:2].[C:11]([CH:15]1[CH2:24][C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:17][NH:16]1)([O:13]C)=[O:12]>>[C:1]([CH2:5][CH:6]([CH3:10])[C:7]([N:16]1[C@H:15]([C:11]([OH:13])=[O:12])[CH2:24][C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:17]1)=[O:8])([OH:3])=[O:2]

Participants

3

Reactant 2

HCID 4685119Methyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylateHCID 14403282Methyl 4-chloro-3-methyl-4-oxobutanoate

Product 1

HCID 86739019HCID 86739019, compound

Procedure

Using the method described in example 8, beginning from 3-carbomethoxy 2-(RS) methylpropionic chloride and 3-(RS) carbomethoxy 1,2,3,4-tetrahydro isoquinoline, the following are obtained successively:

Workup

  1. customthe following are obtained successively

Sources & evidence

ORD record
ord-a68198393d854fc78814035d166907e0
Source dataset
uspto-grants-1983_09
Patent number
US04404206

Reaction notes

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