Thionyl Chloride → HCID 178522683, compound

HRID 1995354Notes

Reaction equation

HRID 1995354 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([OH:10])=O)[CH:3]=1.S(Cl)(Cl)=O.[NH2:15][C:16]1[NH:20][N:19]=[N:18][N:17]=1>>[NH:17]1[C:16]([NH:15][C:8]([C:4]2[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][N:5]=2)=[O:10])=[N:20][N:19]=[N:18]1

Participants

4

Reactant 3

HCID 24386Thionyl ChlorideHCID 2308904-Chloropyridine-2-carboxylic acidHCID 178509299HCID 178509299, compound

Product 1

HCID 178522683HCID 178522683, compoundYield 60.5%

Procedure

1.16 g of 4-chloro-2-pyridinecarboxylic acid, 25 ml of thionyl chloride and 0.82 g of 5-aminotetrazole are treated in the same manner as described in Example 1. The crude product thus obtained is recrystallized from a mixture of dimethylformamide and ethanol, whereby 1.0 g of N-(5-tetrazolyl)-4-chloro-2-pyridinecarboxamide is obtained.

Workup

  1. customThe crude product thus obtained
  2. customis recrystallized from a mixture of dimethylformamide and ethanol

Sources & evidence

ORD record
ord-5e3db7e17e4b4e46acc94f2fc1d9a680
Source dataset
uspto-grants-1983_09
Patent number
US04404214

Reaction notes

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