3,6-Dimethylpyridine-2-carboxylic acid → HCID 178425018, compound

HRID 1995368Notes

Reaction equation

HRID 1995368 reaction equation
[CH3:1][C:2]1[C:3]([C:9]([OH:11])=O)=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.[NH2:12][C:13]1[NH:17][N:16]=[N:15][N:14]=1>>[NH:14]1[C:13]([NH:12][C:9]([C:3]2[C:2]([CH3:1])=[CH:7][CH:6]=[C:5]([CH3:8])[N:4]=2)=[O:11])=[N:17][N:16]=[N:15]1

Participants

3

Reactant 2

HCID 132095673,6-Dimethylpyridine-2-carboxylic acidHCID 178509299HCID 178509299, compound

Product 1

HCID 178425018HCID 178425018, compoundYield 62%

Procedure

0.76 g of 3,6-dimethyl-2-pyridinecarboxylic acid, 0.82 g of N,N'-carbonyldiimidazole and 0.51 g of 5-aminotetrazole are treated in the same manner as described in Example 2. The crude product thus obtained is recrystallized from a mixture of dimethylformamide and ethanol, whereby 0.68 g of N-(5-tetrazolyl)-3,6-dimethyl-2-pyridinecarboxamide is obtained.

Workup

  1. customThe crude product thus obtained
  2. customis recrystallized from a mixture of dimethylformamide and ethanol

Sources & evidence

ORD record
ord-f81060f1a8f549afb37bbcb410250276
Source dataset
uspto-grants-1983_09
Patent number
US04404214

Reaction notes

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