4-Bromopyridine-2-carboxylic acid → HCID 178522650, compound

HRID 1995370Notes

Reaction equation

HRID 1995370 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]([OH:10])=O)[CH:3]=1.[NH2:11][C:12]1[NH:16][N:15]=[N:14][N:13]=1>>[NH:13]1[C:12]([NH:11][C:8]([C:4]2[CH:3]=[C:2]([Br:1])[CH:7]=[CH:6][N:5]=2)=[O:10])=[N:16][N:15]=[N:14]1

Participants

3

Reactant 2

HCID 7351504-Bromopyridine-2-carboxylic acidHCID 178509299HCID 178509299, compound

Product 1

HCID 178522650HCID 178522650, compoundYield 60.1%

Procedure

0.3 g of 4-bromo-2-pyridinecarboxylic acid, 0.25 g of N,N'-carbonyldiimidazole and 0.14 g of 5-aminotetrazole are treated in the same manner as described in Example 2. The crude product thus obtained is recrystallized from a mixture of dimethylformamide and ethanol, whereby 0.24 g of N-(5-tetrazolyl)-4-bromo-2-pyridinecarboxamide is obtained.

Workup

  1. customThe crude product thus obtained
  2. customis recrystallized from a mixture of dimethylformamide and ethanol

Sources & evidence

ORD record
ord-18de6e22dcd745c4bd8731719cfa17b1
Source dataset
uspto-grants-1983_09
Patent number
US04404214

Reaction notes

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