Methanol → HCID 20488603, compound

HRID 1995430Notes

Reaction equation

HRID 1995430 reaction equation
[CH:1]1[CH:6]=[C:5]2[NH:7][C:8]([O:10][C:4]2=[CH:3][CH:2]=1)=[O:9].[CH3:11][NH:12][CH2:13][CH2:14][OH:15].CO>C(OCC)C>[OH:10][C:4]1[CH:3]=[CH:2][CH:1]=[CH:6][C:5]=1[NH:7][C:8]([N:12]([CH3:11])[CH2:13][CH2:14][OH:15])=[O:9]

Participants

5

Reactant 3

HCID 887MethanolHCID 60432(3H)-BenzoxazoloneHCID 80162-(Methylamino)ethanol

Product 1

HCID 20488603HCID 20488603, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
75 °C

Procedure

Benzoxalinone (202 g) and N-methylethanolamine (133 g) were stirred and heated at 75° C. for 3 hours, then cooled to 65° C. and methanol (50 ml) was added. The mixture was cooled to ambient temperature and diethyl ether (750 ml) was added. The precipitate was filtered off and recrystallised from methanol to give the desired urea which had a m.pt. of 128° C. (decomp.).

Workup

  1. temperaturecooled to 65° C.
  2. temperatureThe mixture was cooled to ambient temperature
  3. filtrationThe precipitate was filtered off
  4. customrecrystallised from methanol

Sources & evidence

ORD record
ord-8706ad9a56374f35b7f5f2903f63cc39
Source dataset
uspto-grants-1983_09
Patent number
US04404356

Reaction notes

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