Nitric Acid → HCID 178527981, compound

HRID 1995440Notes

Reaction equation

HRID 1995440 reaction equation
N([O-])=O.[Na+].[N+]([O-])(O)=O.N[N:10]1[C:14]([N:15]2[CH:19]=[CH:18][CH:17]=[N:16]2)=[N:13][N:12]=[C:11]1[SH:20].C([O-])([O-])=O.[Na+].[Na+]>O>[SH:20][C:11]1[N:10]=[C:14]([N:15]2[CH:19]=[CH:18][CH:17]=[N:16]2)[NH:13][N:12]=1

Participants

6

Reactant 4

HCID 944Nitric AcidHCID 10340Sodium CarbonateHCID 23668193Sodium NitriteHCID 178514282HCID 178514282, compound

Product 1

HCID 178527981HCID 178527981, compoundYield 50.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Sodium nitrite (0.4 g) was added to 25 ml of conc HNO3 and 75 ml H2O (after R. A. Henry and W. G. Finnegan, J. Am. Chem. Soc., 76, 290 (1954) and C. A. Amsworth and R. G. Jones J. Am. Chem. Soc., 75, 4915 (1953). Solid 4-amino-3-mercapto-5-(1-pyrazolyl)-1,2,4-triazole (5 g) was added in small batches with stirring while keeping the temperature below 40° C. After addition, the solution was stirred for 20 minutes and made basic by the addition of 15% aq. Na2CO3. The yellow solution was filtered and acidified with glacial acetic acid (25 ml). The tan precipitate was collected and boiled with ethanol to give 2.3 g of tan powder m.p. 245°-247°.

Workup

  1. customthe temperature below 40° C
  2. additionAfter addition
  3. stirringthe solution was stirred for 20 minutes
  4. filtrationThe yellow solution was filtered
  5. customThe tan precipitate was collected

Sources & evidence

ORD record
ord-e999f2325f104d65ae0cd4d32e6289c3
Source dataset
uspto-grants-1983_09
Patent number
US04404374

Reaction notes

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