HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 7-Diethylamino-3-(4-phenylthiazol-2-yl)-iminocoumarin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 4-(Diethylamino)-2-hydroxybenzaldehyde | HCID 87293 | — |
| Reactant | (4-Phenyl-1,3-thiazol-2-yl)acetonitrile | HCID 704539 | — |
| Product | 7-Diethylamino-3-(4-phenylthiazol-2-yl)-iminocoumarin | HCID 86739026 | 81.3% |
Reaction Steps
3.9 parts of 4-diethylaminosalicylaldehyde and 4 parts of 2-cyanomethyl-4-phenyl-thiazole in 40 parts by volume of isopropyl alcohol are refluxed with 0.5 part by volume of pyrrolidine for 1 hour. The reaction mixture is then cooled and the precipitate is filtered off and washed. 6.1 parts (81.3% of theory) of 7-diethylamino-3-(4-phenylthiazol-2-yl)-iminocoumarin, of melting point120°-128° C., are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04404389 |
| Source dataset | uspto-grants-1983_09 |
| ORD ID | ord-26ac398c4c40419f9ba7740429bea8d6 |
| Source note | uspto-grants-1983_09 |