Acetic Anhydride → HCID 20217690, compound

HRID 1995465Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[C:17]3[NH:16]C(C)=[N:14][C:13]=3[C:12](=[O:19])[N:11]3[CH2:20][C:21](C)(C)[N:22]=[C:10]23)=[CH:4][CH:3]=1.C(OC(=O)C)(=O)C>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[C:17]([NH2:16])=[C:13]([NH2:14])[C:12](=[O:19])[N:11]3[CH:20]=[CH:21][N:22]=[C:10]23)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 178432341HCID 178432341, compound

Product 1

HCID 20217690HCID 20217690, compoundYield 70%

Procedure

4-[(4-CHLOROPHENYL)METHYL]-6,7-DIHYDRO-2,6,6-TRIMETHYL-3H-IMIDAZO[1,2-a]PURIN-9(4H)-ONE.- The nitroso compound of Procedure 103 was catalytically hydrogenated to the diamino compound and then treated with acetic anhydride according to the method of Procedure 63. There resulted from this process the mono N-acetyl derivative of 8-[(4-chlorophenyl)methyl]-6,7-diaminoimidazo[1,2-a]pyrimidin-5-one, m.p. 155°-159° after recrystallization from isopropanol and drying under vacuum.

Sources & evidence

ORD record: ord-de6c69e656834915909f1093146ab805
Source dataset: uspto-grants-1983_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04404380

Reaction notes

Loading…