Oxalyl chloride → 2,2-Dimethyl-3-acetyloxypropionyl chloride

Participants

Reaction Steps

Under an argon atmosphere a stirred solution of 1.2 grams (0.008 mole) of 3-acetoxy-2,2-dimethylpropionic acid in 30 ml of toluene was heated to 80° and a solution of 1.9 grams (0.015 mole) of oxalyl chloride in 20 ml of toluene was added dropwise. Upon completion of addition the reaction mixture was heated at 80° for 18 hours. The reaction mixture was concentrated under reduced pressure to give 1.3 grams of 3-acetoxy-2,2-dimethylpropionyl chloride as an oil.

Provenance & Evidence