2-Fluoromethyl-2-phthalimido-5-iodopentanenitrile → 2-Fluoromethyl-2,5-diphthalimidopentanenitrile

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Reaction Steps

A mixture of 2-fluoromethyl-2-phthalimido-5-iodo-valeronitrile (34.1 g), potassium phthalimide (16.6 g), and dry DMF (230 ml) is stirred and heated at 70°-80° C. for 5 hours. The DMF is removed under reduced pressure, the residue is dissolved in chloroform, and the chloroform solution is washed with water (2×), 1 N KOH (2×), 1 N HCl, and water again (3×). The washed chloroform solution is dried and solvent removed to give an oil which is evaporated twice with chloroform/ether to give a solid. Recrystallization from ether (500 ml) gives the pure title compound (18.5 g).

Provenance & Evidence