HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1995600Generated: October 29, 2026
Ammonium Hydroxide → 2-Chloro-5-(4-chlorophenyl)nicotinonitrile
https://huagongshe.com/reaction/1995600
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | Phenylphosphonic dichloride | HCID 69990 | — |
| Reactant | 5-(4-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile | HCID 2763910 | — |
| Product | 2-Chloro-5-(4-chlorophenyl)nicotinonitrile | HCID 2764042 | — |
Reaction Steps
A mixture of 3-cyano-5-(4-chlorophenyl)-2-(1H)-pyridone (2.0 grams) and phenylphosphonic dichloride (3.8 grams) was heated for 4 hours at 175° C. in an oil bath. The mixture was poured into ice water and was made alkaline by stirring with NH4OH. The resulting brownish solid product was used without further purification, yield 2.0 g., m.p. 185°-187° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04405552 |
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| Source dataset | uspto-grants-1983_09 |
|---|
| ORD ID | ord-b17c418dc7b14ed1b9ec25a8755b141b |
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| Source note | uspto-grants-1983_09 |
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