HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 2-Chloro-4,6-dimethyl-5-phenylpyridine-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | Phenylphosphonic dichloride | HCID 69990 | — |
| Reactant | 4,6-Dimethyl-2-oxo-5-phenyl-1,2-dihydropyridine-3-carbonitrile | HCID 261086 | — |
| Product | 2-Chloro-4,6-dimethyl-5-phenylpyridine-3-carbonitrile | HCID 13502853 | — |
Reaction Steps
3-Cyano-4,6-dimethyl-5-phenyl-2-pyridone (7.0 grams) and phenylphosphonic dichloride (12.1 grams) were heated at 175°-180° C. for 2-3 hours. The solution was cooled, poured into ice water and made basic with ammonium hydroxide. A precipitate formed which was collected, air dried, and determined by NMR to be the desired product, yield 7.6 grams, m.p. 118°-123° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04405552 |
| Source dataset | uspto-grants-1983_09 |
| ORD ID | ord-b076809bd7354b92b79fd2dbc213073a |
| Source note | uspto-grants-1983_09 |