Ethylene Glycol → 2-Amino-4,6-dimethyl-5-phenylpyridine-3-carboxylic acid

Participants

Reaction Steps

2-Amino-4,6-dimethyl-5-phenyl-3-pyridinecarbonitrile (0.5 gram) and potassium hydroxide (1.0 gram) were heated in 15 ml ethylene glycol at approximately 165° C. for about 6 hours. The reaction mixture was poured into ice water and then made acidic to a pH of 4-5. A solid formed which was collected, washed with water and identified as the desired product by TLC and NMR.

Provenance & Evidence