2-Amino-4,6-dimethyl-5-phenylpyridine-3-carboxylic acid → 4,6-Dimethyl-5-phenyl-2-pyridylamine

Participants

Reaction Steps

2-Amino-4,6-dimethyl-5-phenyl-3-pyridinecarboxylic acid (6.1 grams) and copper powder (1.0 gram) were heated in 50 ml quinoline at 270°-290° C. for approximately 3 hours. The entire reaction mixture was then chromatographed over 600 ml of Grace 923 silica gel with ether followed by ethyl acetate, yield 3.0 grams of dried product, m.p. 105°-112° C.

Provenance & Evidence