HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenyl phosphorodiamidate → 6-Methyl-5-phenylpyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenyl phosphorodiamidate | HCID 81954 | — |
| Reactant | 6-Methyl-5-phenylpyridin-2(1H)-one | HCID 13502850 | — |
| Solvent | Diphenyl Ether | HCID 7583 | — |
| Product | 6-Methyl-5-phenylpyridin-2-amine | HCID 13502855 | — |
Reaction Steps
A mixture of 6-methyl-5-phenyl-2-pyridone (12.0 grams) and phenylphosphorodiamidate (14.4 grams) in 300 ml diphenyl ether was heated for 19-20 hours at approximately 220°-225° [250]° C. After cooling, the reaction mixture was chromatographed over silica gel with ethyl acetate. A total of 0.8 gram, of desired product was collected and recrystallized from dichloromethane/petroleum ether, m.p. 110°-113° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04405552 |
| Source dataset | uspto-grants-1983_09 |
| ORD ID | ord-8748852fa503406d89d41ac41d6f08d2 |
| Source note | uspto-grants-1983_09 |