2,6-Difluorobenzoyl isocyanate → HCID 13242655, compound

HRID 1995624Notes

Reaction equation

HRID 1995624 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=1.[F:16][C:17]1[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:18]=1[C:19]([N:21]=[C:22]=[O:23])=[O:20]>C(#N)C>[F:16][C:17]1[CH:27]=[CH:26][CH:25]=[C:24]([F:28])[C:18]=1[C:19]([NH:21][C:22]([NH:8][C:6]1[CH:5]=[CH:4][C:3]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)=[C:2]([Cl:1])[N:7]=1)=[O:23])=[O:20]

Participants

4

Reactant 2

HCID 27333692,6-Difluorobenzoyl isocyanateHCID 135028596-Chloro-5-(4-chlorophenyl)pyridin-2-amine

Product 1

HCID 13242655HCID 13242655, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

6-Chloro-5-(4-chlorophenyl)-2-pyridylamine (0.3 gram) was dissolved in 25 ml acetonitrile and treated with 2,6-difluorobenzoyl isocyanate (0.5 gram) under nitrogen at room temperature. A precipitate formed almost immediately and after about three hours stirring, the solid was collected and washed with acetonitrile, yield 0.36 gram, m.p. 237°-241° C.

Workup

  1. customA precipitate formed almost immediately and after about three hours
  2. customthe solid was collected
  3. washwashed with acetonitrile, yield 0.36 gram, m.p. 237°-241° C.

Sources & evidence

ORD record
ord-da6c69a66c5248ae9edc3bbbd4603714
Source dataset
uspto-grants-1983_09
Patent number
US04405552

Reaction notes

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