反应详情

To a melt of 26 g (0.23 mole) of pyridine hydrochloride at 200°-205° C. is added 5.3 g (0.023 mole) of 1,3-dihydro-4-(4-methoxybenzoyl)-5-methyl-2H-imidazol-2-one and the mixture is stirred mechanically for 30 minutes. The reaction mixture is poured on ice-2NHCl. The resulting precipitate is washed with water and recrystallized from isopropanol-water to give the title compound. M.P. >300° C. λ(max)(methanol) 320 nm (ε=13,200).

1. additionThe reaction mixture is poured on ice-2NHCl
2. washThe resulting precipitate is washed with water
3. customrecrystallized from isopropanol-water