HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1995660Generated: October 29, 2026
2-Thiophenecarbonyl chloride → 4-Methyl-5-(thiophene-2-carbonyl)-1,3-dihydro-2H-imidazol-2-one
https://huagongshe.com/reaction/1995660
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Thiophenecarbonyl chloride | HCID 78928 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | HCID 22290139 | HCID 22290139 | — |
| Solvent | Nitrobenzene | HCID 7416 | — |
| Product | 4-Methyl-5-(thiophene-2-carbonyl)-1,3-dihydro-2H-imidazol-2-one | HCID 15567546 | — |
Reaction Steps
To a solution of 7.3 g of 4-methylimidazol-2-one and 10.8 g of aluminum chloride in 150 ml of nitrobenzene is added 12.0 g of 2-thienoyl chloride. The mixture is stirred at 60° C. for 3 hours, cooled and poured over ice water. The organic portion is extracted into ethyl acetate, dried and the organic solvent evaporated to give the title compound. M.P. 212°-215° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04405635 |
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| Source dataset | uspto-grants-1983_09 |
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| ORD ID | ord-35150c29c8e54383be0cb3148ed6df80 |
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| Source note | uspto-grants-1983_09 |
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