2-Hydroxyimidazole → HCID 15567545, compound

HRID 1995663Notes

Reaction equation

HRID 1995663 reaction equation
[Cl-].[Al+3].[Cl-].[Cl-].[NH:5]1[CH:9]=[CH:8][NH:7][C:6]1=[O:10].[S:11]1[CH:15]=[CH:14][CH:13]=[C:12]1[C:16](Cl)=[O:17]>[N+](C1C=CC=CC=1)([O-])=O>[S:11]1[CH:15]=[CH:14][CH:13]=[C:12]1[C:16]([C:9]1[NH:5][C:6](=[O:10])[NH:7][CH:8]=1)=[O:17]

Participants

5

Reactant 3

HCID 222082-HydroxyimidazoleHCID 789282-Thiophenecarbonyl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 15567545HCID 15567545, compound

Reagents, catalysts & solvents 1

HCID 7416NitrobenzeneSolvent

Conditions

Temperature
60 °C

Procedure

In 50 ml of nitrobenzene is combined 13.3 g of aluminum chloride, 4.2 g of 1,3-dihydro-2H-imidazol-2-one and 8.1 g of thienoyl chloride. The mixture is stirred at 60° C. for 3 hours and poured over ice water. The solids are filtered, washed with ether and recrystallized twice from ethanol-water to afford the title compound. M.P. 339°-42° C.

Workup

  1. filtrationThe solids are filtered
  2. washwashed with ether
  3. customrecrystallized twice from ethanol-water

Sources & evidence

ORD record
ord-f7cb1d0d17284292999a43d450b460e3
Source dataset
uspto-grants-1983_09
Patent number
US04405635

Reaction notes

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