Azobisisobutyronitrile → 4-(Difluoromethoxy)benzyl Bromide

Participants

Reaction Steps

270 g of 4-difluoromethoxytoluene in 800 ml of CCl4 were initially introduced and 300 g N-bromo-succinimide were added. After adding a pinch of azobisisobutyronitrile, the mixture was heated to the reflux temperature. After 8 hours, it was cooled, the insoluble succinimide was filtered off and the residue on the filter was washed with CCl4. The carbon tetrachloride was distilled off from the reaction solution and the crude product was purified by fractional distillation. 250 g of 4-difluoromethoxy-benzyl bromide were obtained. Boiling point=82°-5° C./0.4 mm Hg; nD20 =1.5200.

Provenance & Evidence