HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Cyanide → 4-(Trifluoromethylthio)phenylacetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | 1-(Chloromethyl)-4-((trifluoromethyl)sulfanyl)benzene | HCID 2783164 | — |
| Catalyst | Tetraethylammonium Chloride | HCID 5946 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(Trifluoromethylthio)phenylacetonitrile | HCID 2777905 | 123.3% |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
75 g of sodium cyanide were dissolved in 200 ml of water, and 15 g of tetraethylammonium chloride after 450 g of 4-trifluoromethylmercapto-benzyl chloride were added. The reaction mixture was stirred at 110° C. for 1 hour and then cooled. The cold mixture was diluted with 200 ml of water and then extracted twice with methylene chloride. After drying the organic phase, the solvent was distilled off and the crude product was purified by distillation. 410 g of 4-trifluoromethylmercapto-benzyl cyanide were obtained. Boiling point=95°-97° C./1.5 mm Hg; nD20 =1.5025.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04405639 |
| Source dataset | uspto-grants-1983_09 |
| ORD ID | ord-04e50a6e59354db9bcbbbdc7529d2acc |
| Source note | uspto-grants-1983_09 |