HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1995718Generated: October 31, 2026
1,3-dihydro-4-methyl-2H-imidazol-2-one → HCID 12856029, compound
https://huagongshe.com/reaction/1995718
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,3-dihydro-4-methyl-2H-imidazol-2-one | HCID 70935 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | Isonicotinoyl chloride hydrochloride | HCID 12262826 | — |
| Solvent | 1,1,1,2-Tetrachloroethane | HCID 12418 | — |
| Product | HCID 12856029 | HCID 12856029 | — |
Reaction Steps
In 80 ml tetrachloroethane are placed 3.87 g (39.5 mmole) 1,3-dihydro-4-methyl-2H-imidazole-2-one and 7 g (39.5 mmole) isonicotinoyl chloride hydrochloride. Aluminum chloride (26 g, 194 mmole) is added and the mixture is stirred at 85° C. for 3 hours. The tetrachloroethane is decanted from the reaction mixture and the residue is quenched with water and neutralized with sodium bicarbonate. The suspension is filtered and the filtrate evaporated to dryness. Chromatography over silica gel affords the title compound; m.p. 295°-96°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04405628 |
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| Source dataset | uspto-grants-1983_09 |
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| ORD ID | ord-9d15da9ca5f94417a671004e4970add4 |
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| Source note | uspto-grants-1983_09 |
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