HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1995719Generated: October 31, 2026
3-Pyridinecarbonyl chloride, hydrochloride (1:1) → HCID 13599244, compound
https://huagongshe.com/reaction/1995719
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Pyridinecarbonyl chloride, hydrochloride (1:1) | HCID 88438 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | 4-ethyl-2,3-dihydro-1H-imidazol-2-one | HCID 15567528 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,1,1,2-Tetrachloroethane | HCID 12418 | — |
| Product | HCID 13599244 | HCID 13599244 | — |
Reaction Steps
To a well stirred mixture of 8.85 g (50 mmole) nicotinoyl chloride hydrochloride and 5.6 g (50 mmole) 1,3-dihydro-4-ethyl-2H-imidazole-2-one in 100 ml tetrachloroethane is added 22 g (164 mmole) aluminum chloride. The mixture is heated at 85° C. for 2 hours and treated with water. The solution is neutralized with sodium bicarbonate, filtered and taken to dryness. Chromatography over silica gel affords the title compound; m.p. 219°-21°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04405628 |
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| Source dataset | uspto-grants-1983_09 |
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| ORD ID | ord-a9aa95d05a474f9fa67fa9543fed1f1f |
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| Source note | uspto-grants-1983_09 |
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