Formic Acid → HCID 20487787, compound

HRID 1995727Notes

Reaction equation

HRID 1995727 reaction equation
[CH3:1][C:2]1([CH2:21][CH3:22])[N:6]([CH2:7][CH:8]2[O:10][CH2:9]2)[C:5](=[O:11])[C:4]2([CH2:16][C:15]([CH3:18])([CH3:17])[NH:14][C:13]([CH3:20])([CH3:19])[CH2:12]2)[O:3]1.C(O)=[O:24]>>[CH3:1][C:2]1([CH2:21][CH3:22])[N:6]([CH2:7][CH:8]([OH:24])[CH2:9][OH:10])[C:5](=[O:11])[C:4]2([CH2:16][C:15]([CH3:17])([CH3:18])[NH:14][C:13]([CH3:19])([CH3:20])[CH2:12]2)[O:3]1

Participants

3

Reactant 2

HCID 284Formic AcidHCID 20487783HCID 20487783, compound

Product 1

HCID 20487787HCID 20487787, compound

Procedure

50 g of 2,7,7,9,9-pentamethyl-2-ethyl-3-(2,3-epoxypropyl)-1-oxa-3,8-diaza-spiro[4.5]decan-4-one in 200 g of formic acid were boiled under reflux for 4 hours. The formic acid was removed by distillation in vacuo and the residue was boiled for 2 hours in 100 ml of 10% strength NaOH. An oily layer was formed, this was separated off and it solidified after a little time. The product was pulverized, washed with water and dried.

Workup

  1. temperatureunder reflux for 4 hours
  2. customThe formic acid was removed by distillation in vacuo
  3. customAn oily layer was formed
  4. customthis was separated off
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-32d4945ba4fa4f3e8e906a4e9a48bbf0
Source dataset
uspto-grants-1983_09
Patent number
US04405735

Reaction notes

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