Methanesulfonic acid--6-chloro-7H-purine (1/1) → 6-Chloropurine

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Reaction Steps

To 15 ml of water there were added 5 g of 6-chloropurine methansulfonate with vigorous stirring. After stirring for 15 minutes at room temperature the mixture was allowed to stand in a freezer for 1 hour after which the light yellow precipitate which formed was collected by filtration. The filter cake was washed with 5 ml of ice water and dried in a vacuum oven at 55° C. to give 2.6 g (84% yield) of 6-chloropurine, λ max (H2O)=265 nm, ε=9.22×103.

Provenance & Evidence