HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylanisole → p-(Dimethoxymethyl)anisole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylanisole | HCID 7731 | — |
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | p-(Methoxymethyl)anisole | HCID 73689 | — |
| Product | p-(Dimethoxymethyl)anisole | HCID 75140 | 15% |
Reaction Steps
In the article "Nuclear Cyanation of Methylanisoles" by K. Yoshida, M. Shigi and T. Fueno in J. Org. Chem., 1975, Vol. 40, No. 1, pp. 63-66, the reaction of 4-methoxytoluene (Ic) in a methanolic solution of NaCN or Na acetate is described. In this reaction, 4-(methoxymethyl)-anisole and, in a material (current) yield of 15% (24%) of the theoretical, anisaldehyde-dimethylacetal (IIc) are also formed, in addition to the respective ring-substitution products.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04405816 |
| Source dataset | uspto-grants-1983_09 |
| ORD ID | ord-1b82e5949d2b438fa229739f9e648332 |
| Source note | uspto-grants-1983_09 |