Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 5-[(4-Chlorophenyl)methoxy]-2-nitropyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | 1-Chloro-4-(chloromethyl)benzene | HCID 7723 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 6-Nitropyridin-3-ol | HCID 2762857 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 5-[(4-Chlorophenyl)methoxy]-2-nitropyridine | HCID 20486129 | — |
반응 단계
A mixture of 5-hydroxy-2-nitropyridine (7 g), K2CO3 (6.9 g) of DMF (100 ml) is stirred for about 10 minutes. To the mixture is added 4-chlorobenzyl chloride (8.1 g) in portions over about 15 minutes. The reaction mixture is stirred about 16 hours and then heated to 45° for about 30 minutes. After cooling, the reaction is diluted with CHCl3, washed with water and saturated NaCl, dried (Na2SO4) and stripped. The crystalline solid is washed with 20% ethyl acetate/hexane, giving 5-(4-chlorobenzyloxy)-2-nitropyridine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04406690 |
| 출처 데이터셋 | uspto-grants-1983_09 |
| ORD ID | ord-d7b70505cb554565b000a38fca5fc509 |
| 출처 메모 | uspto-grants-1983_09 |