反应详情

A mixture of 5-(4-chlorobenzyloxy)-2-nitropyridine (0.5 g), Na2S (0.25 g) and methanol (12 ml) is heated to reflux for about 3 hours. Then, a few drops of water is added and refluxing continued about 15 hours. After cooling, the reaction is diluted with methanol, filtered through celite and stripped. The concentrate is taken up in CHCl3, washed with water, dried and stripped giving 2-amino-5-(4-chlorobenzyloxy)pyridine.

1. temperatureis heated
2. temperatureto reflux for about 3 hours
3. temperaturerefluxing
4. temperatureAfter cooling
5. filtrationfiltered through celite
6. washwashed with water
7. customdried