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Dimethylformamide → 5-[(4-Chlorophenyl)methoxy]-2-nitropyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 1-Chloro-4-(chloromethyl)benzene | HCID 7723 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 6-Nitropyridin-3-ol | HCID 2762857 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 5-[(4-Chlorophenyl)methoxy]-2-nitropyridine | HCID 20486129 | — |
反応手順
A mixture of 5-hydroxy-2-nitropyridine (7 g), K2CO3 (6.9 g) and DMF (100 ml) is stirred for about 10 minutes. To the mixture is added 4-chlorobenzyl chloride (8.1 g) in portions over about 15 minutes. The reaction mixture is stirred about 16 hours and then heated to 45° for about 30 minutes. After cooling, the reaction is diluted with CHCl3, washed with water and saturated NaCl, dried (Na2SO4) and stripped. The crystalline solid is washed with 20% ethyl acetate/hexane, giving 5-(4-chlorobenzyloxy)-2-nitropyridine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04406689 |
| 出典データセット | uspto-grants-1983_09 |
| ORD ID | ord-8574f42884ea46eba38e5ea78c5e082c |
| 出典メモ | uspto-grants-1983_09 |