4-Chlorophenol → 1-(4-Chlorophenoxy)-4-(4-chlorophenylmercapto)-3,3-dimethyl-butan-2-one

Participants

Reaction Steps

133.7 g (0.41 mol) of 1-bromo-4-(4-chlorophenylmercapto)-3,3-dimethyl-butan-2-one were heated to 100° C. with 64 g (0.5 mol) of 4-chlorophenol and 69 g (0.5 mol) of potassium carbonate in 500 ml of toluene for 5 hours. The mixture was then allowed to cool and was filtered. The filtrate was extracted by shaking with dilute sodium hydroxide solution, rinsed with water, dried over sodium sulphate and concentrated by distilling off the solvent in vacuo. 110.5 g (72% of theory) of 1-(4-chlorophenoxy)-4-(4-chlorophenylmercapto)-3,3-dimethyl-butan-2-one were obtained as a yellowish oil with a refractive index nD20 of 1.5932.

Provenance & Evidence