Sodium borohydride → 1-(4-Chlorophenoxy)-4-(4-chlorophenylmercapto)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-butan-2-ol

Participants

Reaction Conditions

Reaction Steps

0.35 g (0.0092 mol) of sodium borohydride in 8 ml of water was added in portions to 10 g (0.023 mol) of 1-(4-chlorophenoxy)-4-(4-chlorophenylmercapto)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-butan-2-one (Example 4e) in 200 ml of methanol. The reaction mixture was subsequently stirred at 20° C. for 4 hours, poured onto water and extracted with ether. The ether phase was dried over sodium sulphate and concentrated. 5.5 g (54.6% of theory) of 1-(4-chlorophenoxy)-4-(4-chlorophenylmercapto)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-butan-2-ol of melting point 132° C. were obtained.

Provenance & Evidence