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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1995945Generated: October 25, 2026

Dimethyl Sulfate → 5-bromo-7-fluoro-1-methyl-1H-indazole

https://huagongshe.com/reaction/1995945

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethyl SulfateHCID 6497—
Reactant5-Bromo-7-fluoro-1H-indazoleHCID 66793110—
ReagentLithium magnesium 2,2,6,6-tetramethylpiperidin-1-ide dichlorideHCID 25150783—
Solvent2-Methyl-2-butanolHCID 6405—
Product5-bromo-7-fluoro-1-methyl-1H-indazoleHCID 84056882—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-309c96ac86ff46869b7f6d098eaf8096
Source note39k HTE dataset from Pfizer