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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1996413Generated: October 28, 2026

tert-Butyl 3-amino-3-methylpyrrolidine-1-carboxylate → Tert-butyl 3-(4-chloro-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl)-3-methylpyrrolidine-1-carboxylate

https://huagongshe.com/reaction/1996413

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl 3-amino-3-methylpyrrolidine-1-carboxylateHCID 57415917—
ReactantHCID 178505284HCID 178505284—
ReagentLithium HexamethyldisilazideHCID 2733832—
Solvent2-Methyl-2-butanolHCID 6405—
ProductTert-butyl 3-(4-chloro-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl)-3-methylpyrrolidine-1-carboxylateHCID 123726091—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature50 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-b96f09f54a024bae95b4e91dcd714989
Source note39k HTE dataset from Pfizer