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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1996444Generated: October 30, 2026

tert-Butyl 3-amino-3-methylpyrrolidine-1-carboxylate → Tert-butyl 3-(4-chloro-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl)-3-methylpyrrolidine-1-carboxylate

https://huagongshe.com/reaction/1996444

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl 3-amino-3-methylpyrrolidine-1-carboxylateHCID 57415917—
ReactantHCID 178505284HCID 178505284—
Reagent2,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramineHCID 3393106—
SolventTetrahydrofuranHCID 8028—
ProductTert-butyl 3-(4-chloro-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl)-3-methylpyrrolidine-1-carboxylateHCID 123726091—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature80 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-fb3d0f5f297b4c7cba1ca416022ec477
Source note39k HTE dataset from Pfizer